This technical brief highlights key factors that influence newborn nutritional outcomes and the evidence-based practices that can be applied globally to support optimal infant nutrition within the first 28 days. While the focus is primarily on proven interventions that support the mother and newborn, this brief also identifies areas where further research and policy action are needed to adequately support those with special circumstances—such as adolescents, obese women, women suffering maternal depression, and those with limited to no access to quality health care.